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KMID : 0438420100170010025
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Korean Journal of Bone Metabolism
2010 Volume.17 No. 1 p.25 ~ p.29
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The Relationship between Serum Serotonin and Bone Mineral Density in Postmenopausal Women
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Lim Jun-Uk
Chin Sang-Ouk
Hwang You-Chul
Jeong In-Kyung
Ahn Kyu-Jeung
Chung Ho-Yeon
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Abstract
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Objective: Recent studies have suggested that serotonin acts as a mediator of the bone metabolism and suppresses osteoblast proliferation by binding to its receptor in bone. Several studies reported that bone mineral density (BMD) was lower in those who used selective serotonin reuptake inhibitors (SSRIs) which increased extracellular serotonin levels. We investigated the relationship between serum serotonin and BMD.
Methods: Seventy six postmenopausal women with osteoporosis or osteopenia were enrolled in this study. We checked serum serotonin level to determine whether the high level of serotonin is associated with the lowering effect of BMD. In addition, the association between bone turnover markers (osteocalcin, C-terminal telopeptide of collagen cross-links, CTX) was investigated. BMD was measured at lumbar spine, femur neck and total hip by dual energy X-ray absorptiometry (DXA).
Results: There was negative correlation between serum serotonin and lumbar spine BMD (P = 0.0145). However, there was no statistically significant relationship between serotonin and other bone turn over makers.
Conclusion: Serum serotonin was significantly and negatively correlated with lumbar spine BMD.
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KEYWORD
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Serotonin, Bone mineral density, Osteoporosis
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